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MRCPUK SEND Exam Syllabus Topics:
| Section | Objectives |
|---|---|
| Topic 1: Calcium, Bone and Metabolic Disease | - Osteoporosis and metabolic bone disease - Calcium and vitamin D disorders |
| Topic 2: Diabetes Mellitus | - Type 1 and Type 2 diabetes management - Diabetic complications and emergencies |
| Topic 3: Adrenal Disorders | - Cushing syndrome - Addison disease and adrenal insufficiency |
| Topic 4: Thyroid Disease | - Hyperthyroidism and hypothyroidism - Thyroid nodules and cancer |
| Topic 5: Endocrine Emergencies | - Diabetic ketoacidosis and hyperosmolar states - Thyroid and adrenal crisis |
| Topic 6: Metabolic Disorders | - Obesity management - Lipid disorders |
| Topic 7: Reproductive Endocrinology | - Hypogonadism and infertility - Polycystic ovary syndrome (PCOS) |
| Topic 8: Neuroendocrine Tumours and Multiple Endocrine Neoplasia | - MEN syndromes - Carcinoid and pancreatic NETs |
| Topic 9: Pituitary and Hypothalamic Disorders | - Diabetes insipidus and SIADH - Pituitary adenomas and hypopituitarism |
MRCPUK Endocrinology and Diabetes (Specialty Certificate Examination) Sample Questions:
Question 1
A 54-year-old man was referred to the diabetes foot clinic with a plantar foot ulcer of 3 months' duration under the right first metatarsal head. He had a 10-year history of type 2 diabetes mellitus. He lived alone and had to do his own shopping and cleaning.
On examination, the ulcer was 3 ? 2 cm in area, 4 mm in depth, and had a clean granulating base. He had strong palpable pedal pulses and sensory neuropathy in both feet.
What is the most effective intervention to heal this ulcer?
A. total contact casting
B. long-term oral antibiotics
C. ambulatory vacuum-assisted pump therapy
D. removable pressure-relieving boot
E. Manuka honey-impregnated wound dressing
Question 2
A 16-year-old boy was referred to the endocrine clinic. He was concerned about his growth and pubertal development. He was well with no significant medical history. He had felt his development had lagged behind his peers for the previous 2 years and he had been the shortest in his class for some time and was being bullied.
General examination was normal. His height was 1.53 m and weight 52.4 kg. He had Tanner stage 3 genitalia and pubic hair. Axillary hair was present. Testicular volumes were 6 mL bilaterally.
Investigations:
serum testosterone4.4 nmol/L (9.0-35.0)
plasma follicle-stimulating hormone2.5 U/L (1.0-7.0)
plasma luteinising hormone1.8 U/L (1.0-10.0)
serum insulin-like growth factor 134.5 nmol/L (9.3-56.0)
insulin tolerance test:
What is the most appropriate treatment?
A. growth hormone 0.4 mg subcutaneously per day
B. testosterone 50 mg intramuscularly per month
C. hydrocortisone 15 mg am, 5 mg pm
D. testosterone 250 mg intramuscularly per month
E. reassure and review
Question 3
A 32-year-old woman with a recurrent history of Graves' thyrotoxicosis was being considered for radioiodine treatment. However, she wanted to conceive again at some stage and asked how soon she could become pregnant.
After what minimum interval would it be safe for her to conceive again?
A. 6 months
B. 12 months
C. 8 months
D. 2 months
E. 4 months
Question 4
A 63-year-old woman with diet-controlled type 2 diabetes mellitus was admitted with biventricular cardiac failure. She had a history of myocardial infarction 3 years previously. She was taking aspirin 75 mg daily, simvastatin 20 mg daily, furosemide 40 mg daily and ramipril 10 mg daily. She responded well to increased diuretic therapy.
Urinalysis showed glucose 1+.
Investigations:
haemoglobin112 g/L (115-165)
serum sodium135 mmol/L (137-144)
serum potassium4.7 mmol/L (3.5-4.9)
serum creatinine162 umol/L (60-110)
estimated glomerular filtration rate28 mL/min/1.73 m2 (>60)
serum troponin T<0.01 ug/L (<0.01)
haemoglobin A1c66 mmol/mol (20-42)
What is the most appropriate treatment for her diabetes after discharge?
A. exenatide
B. gliclazide
C. linagliptin
D. dapagliflozin
E. subcutaneous insulin
Question 5
A 40-year-old man presented with a 4-month history of increasing central obesity. His medical history included HIV infection and allergic rhinitis. He was taking highly active antiretroviral therapy and nasal fluticasone.
On examination, he had marked central adiposity. His blood pressure was 160/95 mmHg.
Investigations:
serum sodium140 mmol/L (137-144)
serum potassium3.8 mmol/L (3.5-4.9)
serum cholesterol5.5 mmol/L (<5.2)
fasting serum triglycerides8.20 mmol/L (0.45-1.69)
serum cortisol (09.00 h)<50 nmol/L (200-700)
serum thyroid-stimulating hormone4.6 mU/L (0.4-5.0)
serum free T49.3 pmol/L (10.0-22.0)
What is the most likely diagnosis?
A. hypothyroidism
B. HIV-associated lipodystrophy
C. glucocorticoid resistance
D. Addison's disease
E. Cushing's syndrome
Solutions:
| Question 1 Answer: A | Question 2 Answer: B | Question 3 Answer: A | Question 4 Answer: B | Question 5 Answer: E |








